| Drug Name |
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| Synonyms |
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| #Ro5 Violations (Lipinski): 1 |
Molecular Weight (mw) |
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| Logarithm of the Partition Coefficient (xlogp) |
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| Rotatable Bond Count (rotbonds) |
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| Hydrogen Bond Donor Count (hbonddonor) |
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| Hydrogen Bond Acceptor Count (hbondacc) |
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| ADMET Property |
- Absorption Tmax
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The time to maximum plasma concentration (Tmax) is 0.75 h
[1]
- Bioavailability
-
The bioavailability of drug is 25%
[1]
- Clearance
-
The apparent oral clearance of drug is 159 L/h
[1]
- Elimination
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After administration of a single 100 mg radiolabelled acalabrutinib dose in healthy subjects, 84% of the dose was recovered in the feces and 12% of the dose was recovered in the urine
[1]
- Half-life
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The concentration or amount of drug in body reduced by one-half in 0.9 (with a range of 0.6 - 2.8) hours
[1]
- Metabolism
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The drug is metabolized via the CYP3A enzymes
[1]
- Vd
-
The volume of distribution (Vd) of drug is 34 L
[1]
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| Cross-matching ID |
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